Both Rasmus Højlund and Leny Yoro sustained injuries and had to leave the game early.
The two players were substituted in the first half at SoFi Stadium.
Højlund, who scored United’s opening goal, lasted only 13 minutes before suffering what appeared to be a muscle injury.
He managed to walk off the pitch and went straight down the tunnel.
Yoro, a £52 million summer signing from Lille, was replaced midway through the first half.
The 18-year-old was seen limping as he made his way to the dressing room